Endothelial Nitric Oxide and Cardiovascular Health

Nitric oxide (NO) produced by the endothelium plays a pivotal role in maintaining vascular homeostasis and cardiovascular health. This session will explore the critical functions of endothelial NO in regulating blood vessel tone, inhibiting platelet aggregation, reducing inflammation, and preventing atherosclerosis. We will examine the molecular pathways involved in NO synthesis, including the role of endothelial nitric oxide synthase (eNOS) and its regulation by factors like shear stress, hormones, and oxidative stress. Additionally, the session will focus on therapeutic strategies aimed at enhancing NO production, such as nitrates, phosphodiesterase inhibitors, and lifestyle interventions, to prevent and treat cardiovascular diseases like hypertension, heart failure, and atherosclerosis.

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